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LEADER 00000cam a2200265   4500 
001    u45711 
003    SIRSI 
008    180611s2016    enka     b    001 0 eng u 
020    9780198717348 
049    Jurf 
050 00 RC268.4|b.P425 2016 
100 1  Pecorino, Lauren 
245    Molecular biology of cancer :|bmechanisms, targets, and 
       therapeutics /|cLauren Pecorino, University of Greenwich. 
250    4th ed 
260    Oxford, United Kingdom :|bOxford University Press,|c[2016]
300    xviii, 375 pages :|billustrations (some color) ;|c25 cm. 
504    Includes bibliographical references and index. 
505 0  1 Introduction -- 1.1 What is cancer? -- 1.2 Evidence 
       suggests that cancer is a disease of the genome at 
       cellular level -- 1.3 Influential factors in human 
       carcinogenesis -- 1.4 Principles of conventional cancer 
       therapies -- 1.5 Clinical trials -- 1.6 The role of 
       molecular targets in cancer therapies -- 2 DNA structure 
       and stability: mutations versus repair -- 2.1 Gene 
       structure -- two parts of a gene : the regulatory region 
       and the coding region -- 2.2 Mutations -- 2.3 Carcinogenic
       agents -- 2.4 DNA repair and predispositions to cancer -- 
       Therapeutic strategies -- 2.5 Conventional therapies : 
       chemotherapy and radiation therapy -- 2.6 Strategies that 
       target DNS repair pathways -- 3 Regulation of gene 
       expression -- 3.1 Transcription factors and 
       transcriptional regulation -- 3.2 Chromatin structure -- 
       3.3 Epigenetic regulation of transcription -- 3.4 Evidence
       of a role for epigenetics in carcinogenesis -- 3.5 long 
       non-coding RNAs -- 3.6 MicroRNAs (miRNAs) and regulation 
       of mRNA expression -- 3.7 Telomeres and telomerase -- 
       Therapeutic strategies -- 3.8 Epigenomic and histonomic 
       drugs -- 3.9 Non-coding RNAs for diagnosis -- 3.10 
       Telomerase inhibitors -- 4 Growth factor signaling and 
       oncogenes -- 4.1 Epidermal growth factors signaling: an 
       important paradigm -- 4.2 Oncogenes -- Therapeutic 
       strategies -- 4.3 Kinases as drug targets -- 5 The cell 
       cycle -- 5.1 Cyclins and cyclin-dependent kinases (cdks) -
       - 5.2 Mechanisms of cdk regulation -- 5.3 Progression 
       through the G1 checkpoint -- 5.4 The G2 checkpoint -- 5.5 
       The mitotic checkpoint -- 5.6 The cell cycle and cancer --
       Therapeutic cancer -- 5.7 Cyclin-dependent kinase 
       inhibitors -- 5.8 Other cell cycle kinase targets -- 5.9 
       Inhibitors of the mitotic spindle -- 6 Growth inhibitor 
       and tumor suppressor genes -- 6.1 Definitions of tumor 
       suppressor genes -- 6.2 The retinoblastoma gene -- 6.3 
       Mutations in the RB pathway and cancer -- 6.4 The p53 
       pathway -- 6.5 Mutations in the p53 pathway and cancer -- 
       6.6 Interaction of DNA viral protein products with RB and 
       p53 -- Therapeutic strategies -- 6.7 Targeting of the p53 
       pathway -- 7 Apoptosis -- 7.1 Molecular mechanisms of 
       apoptosis -- 7.2 Apoptosis and cancer -- 7.3 Apoptosis and
       chemotherapy -- 7.4 Apoptotic drugs -- 8 Cancer stem cells
       and the regulation of self-renewal and differentiation 
       pathways : focus on colon cancer and leukemias -- 8.1 
       Cancer stem cells -- 8.2 The regulation of differentiation
       by gene expression -- Therapeutic strategies -- 8.3 
       Inhibitors of the Wnt pathway -- 8.4 Inhibitors of the Hh 
       pathway -- 8.5 Inhibitors of PcG proteins -- 8.6 Leukemia 
       and differentiation therapies -- 9 Metastasis -- 9.1 How 
       do tumors spread? -- 9.2 The process of metastasis -- 9.3 
       Invasion and the epithelial-mesenchymal transition -- 9.4 
       Intravasation -- 9.5 Transport -- 9.6 Extravasation -- 9.7
       Metastatic colonization -- Therapeutic strategies -- 9.8 
       Metalloproteinase inhibitors (MPIs) -- 9.9 Strategies for 
       restoring metastasis suppressors -- 9.10 Targeting several
       steps of metastasis at once -- 10 Angiogenesis -- 10.1 The
       angiogenic switch -- 10.2 Cell behavior during angiogenic 
       sprouting -- 10.3 Other means of tumor neovascularization 
       -- Therapeutic strategies -- 10.4 Anti-angiogenic therapy 
       -- 10.5 Vascular targeting by vascular disrupting agents -
       - 11 Nutrient and hormone effects on the genome -- 11.1 
       Introduction to food and cancer -- 11.2 Causative factors 
       -- 11.3 Preventative factors : microconstituents of fruits
       and vegetables -- 11.4 Reprogramming energy metabolism in 
       tumor cells -- an emerging hallmark of cancer -- 11.5 
       Genetic polymorphisms and diet -- 11.6 Vitamin D : a link 
       between nutrients and hormone action -- 11.7 Hormones and 
       cancer -- Therapeutic strategies -- 11.8 "Enhanced" foods 
       and dietary supplements for chemoprevention -- 11.9 Drugs 
       that target energy pathways -- 11.10 Drugs that target 
       energy pathways -- 11.10 Drugs that target estrogen -- 12 
       Tumor immunology and immunotherapy -- 12.1 Lymphocytes : B
       cells and T cells -- 12.2 The tumor suppressive roles of 
       the immune system -- 12.3 Immune checkpoints -- 12.4 
       Cancer immunoediting and tumor promotion -- 12.5 
       Mechanisms of avoiding immune destruction -- Therapeutic 
       strategies -- 12.6 Therapeutic antibodies -- 12.7 Cancer 
       vaccines -- 12.8 Immune checkpoints blockades -- 12.9 
       Adoptive T-cell transfer, modified T-cell receptors, and 
       chimeric antigen receptors -- 12.10 Oncolytic viruses and 
       virotherapy -- 13 Infectious agents and inflammation -- 
       13.1 Identifying infectious agents as carcinogens -- 13.2 
       Inflammation and cancer -- Therapeutic strategies -- 13.3 
       A national vaccination program against hepatitis B virus 
       in Taiwan -- 13.4 Eradication of H. pylori and the 
       relationship to prevention of gastric cancer -- 13.5 
       Cancer vaccines to prevent cervical cancer -- 13.6 
       Inhibition of inflammation -- 14 Technology and drug and 
       diagnostics development -- 14.1 Microarrays and gene 
       expression profiling -- 14.2 Analysis of biomarkers for 
       diagnostics and prognostics -- 14.3 Studying gene function
       by CRISPR-Cas9 -- 14.4 Imaging -- 14.5 Cancer 
       nanotechnology -- 14.6 Strategies of drug development -- 
       14.7 Development of imatinib -- 14.8 Second- and third-
       generation therapeutics -- 14.9 Improved clinical trial 
       design -- 14.10 Personalized medicine and bioinformatics -
       - 14.11 Are we making progress? -- Appendix 1 : Cell cycle
       regulation -- Glossary -- Index. 
520    "The most engaging and accessible account of cancer 
       biology that makes the link between our understanding of 
       cancer and the development of new therapeutics crystal 
       clear. -- Molecular Biology of Cancer: Mechanisms, Targets,
       and Therapeutics offers an engaging and manageable route 
       into the complex subject of cancer biology. Using the 
       hallmarks of cancer as a foundation, the book describes 
       the cellular and molecular mechanisms underpinning the 
       transformation of healthy cells into cancer cells. -- 
       after discussing a specific biological hallmark of cancer,
       each chapter shows how this knowledge can be directly 
       applied to the development of new targeted therapies, 
       giving you a clear appreciation of how the theory 
       translated to tackling the disease. The new edition gives 
       a contemporary account of the field, drawing on the latest
       research but presenting it in a manner that you will find 
       easy to understand. -- New to this edition: *New full 
       colour diagrams help you visualize key concepts more 
       effectively *Separate chapters for growing areas of cancer
       biology: Metastasis, Angiogenesis, Infectious Agents and 
       Inflammation, and Technology and Drug and Diagnostics 
       Development *Coverage of range of new topics, including 
       immune checkpoints, studying gene function by CRISPR-Ca9, 
       newly proposed mechanisms for the role of obesity in 
       cancer, non-coding RNAs, and the role of exosomes in 
       intercellular communication *Latest details of newly 
       approved therapeutics" -- from back of book 
650  0 Cancer|xMolecular aspects 
650  0 Cancer cells