| Description |
lv,824 p : ill (some color) ; 25 cm. |
| Series |
Advances in experimental medicine and biology ; v. 854 |
|
Advances in experimental medicine and biology ; v. 854
|
| Note |
"The XVI International Symposium on Retinal Degeneration (also known as RD2014) was held from July 13-18, 2014 at the Asilomar Conference Center, Pacific Grove, California,USA"--Page vii. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination -- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium -- Regulation of Retinal Development Via the Epigenetic Modification of Histone --The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis -- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line --The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine -- Receptor 4 -- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina -- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro -- Cell Fate of Müller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish -- Polymodal Sensory Integration in Retinal Ganglion Cells -- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo -- Part X Retinal Pigment Epithelium (RPE) -- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells -- Live Imaging of LysoTracker- Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo -- Cre Recombinase: You Can?t Live with It, and You Can?t Live without It -- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells -- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1 -- Lysosomal Trafficking Regulator (LYST)-- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells -- RPE Cell and Sheet Properties in Normal and Diseased Eyes -- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival Aft. |
| Summary |
Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who spoke and presented posters at the meeting contributed to this volume. The Symposium addressed the blinding diseases of inherited retinal degenerations, which have no effective treatments, and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium focused on the excitingew developments aimed at understanding these diseases and providing therapies for them. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinica aspects; animal models; mechanisms of cell death; molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy; and several sight restoration approaches, including optogenetics. While advances in these areas of retinal degenerations are included, several new topics either were in their infancy or did not exist at the time of the last RD Symposium,RD2012. These include many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices. In addition, major advances are presented in other basic mechanisms in age-related maculardegeneration, several new aspects of gene and antioxidant therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials.The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS.Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those are reported at the RD2014 meeting and included in this volume |
| Subject |
Retinal degeneration
|
| Added Author |
Rickman, Catherine Bowes, editor
|
| ISBN |
9783319171203 |
|
