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LEADER 00000cam a2200253 a 4500 
001    u45697 
003    SIRSI 
008    080621s2018    xxua     b    001 0 eng d 
020    9783030092214 
050 00 RE661.D3 |bR48 2018 
245 10 Retinal degenerative diseases :|bmechanisms and 
       experimental therapy /|cedited by John D. Ash, Robert E. 
       Anderson, Matthew M. LaVail, Catherine Bowes Rickman, Joe 
       G. Hollyfield, Christian Grimm. 
250    1st ed. 2018. 
260    Cham : |b Springer International Publishing : |b Imprint: 
       Springer, |c 2018. 
300    XLII, 669 p :|b142 illustrations, 93 illustrations in 
       color ;|c24 cm. 
490    Advances in Experimental Medicine and Biology, |x 0065-
       2598 ; |v 1074 
500    "The XVI International Symposium on Retinal Degeneration 
       (also known as RD2014) was held from July 13-18, 2014 at 
       the Asilomar Conference Center, Pacific Grove, California,
       USA"--Page vii. 
504    Includes bibliographical references and index. 
520    The blinding diseases of inherited retinal degenerations 
       have no treatments, and age-related macular degeneration 
       has no cures, despite the fact that it is an epidemic 
       among the elderly, with 1 in 3-4 affected by the age of 
       70. The RD Symposium will focus on the exciting new 
       developments aimed at understanding these diseases and 
       providing therapies for them. Since most major scientists 
       in the field of retinal degenerations attend the biennial 
       RD Symposia, they are known by most as the "best" and 
       "most important" meetings in the field. The volume will 
       present representative state-of-the-art research in almost
       all areas of retinal degenerations, ranging from 
       cytopathologic, physiologic, diagnostic and clinical 
       aspects; animal models; mechanisms of cell death; 
       candidate genes, cloning, mapping and other aspects of 
       molecular genetics; and developing potential therapeutic 
       measures such as gene therapy and neuroprotective agents 
       for potential pharmaceutical therapy. While advances in 
       these areas of retinal degenerations will be described, 
       there will be many new topics that either were in their 
       infancy or did not exist at the time of the last RD 
       Symposium, RD2014. These include the role of inflammation 
       and immunity, as well as other basic mechanisms, in age-
       related macular degeneration, several new aspects of gene 
       therapy, and revolutionary new imaging and functional 
       testing that will have a huge impact on the diagnosis and 
       following the course of retinal degenerations, as well as 
       to provide new quantitative endpoints for clinical trials.
       The retina is an approachable part of the central nervous 
       system (CNS), and there is a major interest in 
       neuroprotective and gene therapy for CNS diseases and 
       neurodegenerations, in general. It should be noted that 
       with successful and exciting initial clinical trials in 
       neuroprotective and gene therapy, including the 
       restoration of sight in blind children, the retinal 
       degeneration therapies are leading the way towards new 
       therapeutic measures for neurodegenerations of the CNS. 
       Many of the successes recently reported in these areas of 
       retinal degeneration sprang from collaborations 
       established at previous RD Symposia, and many of those 
       will be reported at the RD2018 meeting and included in the
       proposed volume. We anticipate the excitement of those 
       working in the field and those afflicted with retinal 
       degenerations will be reflected in the volume. 
650  0 Neurosciences. 
650  0 Ophthalmology. 
650  0 Neurosciences. |0 https://scigraph.springernature.com/
       ontologies/product-market-codes/B18006 
650  0 Ophthalmology. |0 https://scigraph.springernature.com/
       ontologies/product-market-codes/H44004 
700 1  Anderson, Robert E. |e editor. 
700 1  Ash, John D. |e editor. 
700 1  Bowes Rickman, Catherine. |e editor. 
700 1  Grimm, Christian. |e editor. 
700 1  Hollyfield, Joe G. |e editor. 
700 1  LaVail, Matthew M. |e editor. 
830  0 Advances in experimental medicine and biology ;|vv. 854