| Edition |
2nd ed |
| Description |
xi, 744 p.: ill.; 24 cm. |
| Series |
Drugs and the pharmaceutical sciences ; 179
|
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland -- In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa -- Human cytochromes P450 and their role in metabolism-based drug- drug interactions / Stephen E. Clarke and Barry C. Jones -- UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar -- Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama -- In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith -- In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie ... [et al.] -- The role of P-glycoprotein in drug disposition: significance to drug development / Matthew D. Troutman ... [et al.] -- Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen -- Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen -- Mechanism-based inhibition of human cytochromes P450: in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall -- Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin -- Metabolism and transport drug interaction database: a web- based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and René H. Levy -- In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson -- Drug-drug interactions: clinical perspective / David J. Greenblatt and Lisa L. von Moltke -- An integrated approach to assessing drug-drug interactions: a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple -- Drug-drug interactions: toxicological perspectives / Sidney D. Nelson -- Drug-drug interactions: marketing perspectives / Kevin J. Petty and Jose M. Vega. |
| Subject |
Drug interactions
|
|
Pharmacokinetics
|
| Added Author |
Rodrigues, A. David
|
| ISBN |
9780849375934 (hb : alk. paper) |
|
0849375932 (hb : alk. paper) |
|
