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LEADER 00000cam a2200337 a 4500 
001    u45144 
003    SIRSI 
008    180320s2016    xxua     b    001 0 eng d 
020    9789814670241 
020    9780071830935 (hardcover : alk. paper) 
020    0071830936 (hardcover : alk. paper) 
020    9814670243 (pbk.) 
050 00 RM301.4 |b.S52 2016 
245 10 Applied biopharmaceutics & pharmacokinetics / |cedited by 
       Leon Shargel and Andrew B.C. Yu. 
246 3  Applied biopharmaceutics and pharmacokinetics. 
246 14 Shargel & Yu's Applied biopharmaceutics and 
       pharmacokinetics. 
250    7th ed. 
260    New York :|bMcGraw-Hill Education,|c2016. 
300    xvii, 910 p : |bill (some color) ;|c24 cm. 
504    Includes bibliographical references and index. 
505 0  Introduction to biopharmaceutics and pharmacokinetics -- 
       Mathematic fundamentals in pharmacokinetics -- 
       Biostatistics -- One compartment open model : IV bolus 
       injection -- Multicompartmental models : IV bolus 
       injection -- Intravenous infusion -- Drug elimination and 
       clearance -- Pharmacokinetics of oral absorption -- 
       Multiple dosage regimens -- Nonlinear pharmacokinetics -- 
       Physiologic drug distribution and protein binding -- Renal
       and hepatic elimination of drugs -- Pharmacogenetics and 
       drug metabolism -- Physiologic factors related to drug 
       absorption -- Biopharmaceutic considerations in drug 
       product design -- Drug product performance, in vivo : 
       bioavailability and bioequivalence -- Biopharmaceutic 
       aspects of the active pharmaceutical ingredient and 
       pharmaceutical equivalence -- Impact of biopharmaceutics 
       on drug product quality and clinical efficacy -- Modified 
       release drug products and drug devices -- Targeted drug 
       delivery systems and biotechnology products -- 
       Relationship between pharmacokinetic and pharmacodynamics 
       -- Application of pharmacokinetics in clinical situations 
       -- Application of pharmacokinetics in specific populations
       -- Dosage adjustment in renal and hepatic disease -- 
       Empirical models, mechanistic models, statistical moment 
       and noncompartmental analysis. 
650  0 Biopharmaceutics 
650  0 Pharmacokinetics 
700 1  Shargel, Leon, |d1941- , |eeditor 
700 1  Yu, Andrew B. C., |d1945-, |eeditor