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LEADER 00000cam a2200253 a 4500 
001    u45697 
003    SIRSI 
008    180607s2016    xxua     b    001 0 eng d 
020    9783319171203 
050 00 RE661.D3 |bR48 2016 
245 10 Retinal degenerative diseases :|bmechanisms and 
       experimental therapy /|cCatherine Bowes Rickman... [et 
       al.]. 
260    New York :|bSpringer,|c2016. 
300    lv,824 p :|bill (some color) ;|c25 cm. 
490    Advances in experimental medicine and biology ;|vv. 854 
500    "The XVI International Symposium on Retinal Degeneration 
       (also known as RD2014) was held from July 13-18, 2014 at 
       the Asilomar Conference Center, Pacific Grove, California,
       USA"--Page vii. 
504    Includes bibliographical references and index. 
505    Mouse Models by Single-Flash and Flicker 
       Electroretinograms without Adapting Background 
       Illumination -- The Role of Intraflagellar Transport in 
       the Photoreceptor Sensory Cilium -- Regulation of Retinal 
       Development Via the Epigenetic Modification of Histone --
       The Potential Role of Flavins and Retbindin in Retinal 
       Function and Homeostasis -- Identification of Tyrosine O 
       Sulfated Proteins in Cow Retina and the 661W Cell Line --
       The Function of Arf-like Proteins ARL2 and ARL3 in 
       Photoreceptors.-Characterization of Antibodies to Identify
       Cellular Expression of Dopamine -- Receptor 4 -- A 
       Possible Role of Neuroglobin in the Retina After Optic  
       Nerve Injury: A Comparative Study of Zebrafish and Mouse 
       Retina -- JNK Inhibition Reduced Retinal Ganglion Cell 
       Death After Ischemia/Reperfusion In Vivo and After Hypoxia
       In Vitro -- Cell Fate of Müller Cells During Photoreceptor
       Regeneration in an MNU-induced Retinal Degeneration Model 
       of Zebrafish -- Polymodal Sensory Integration in Retinal 
       Ganglion Cells -- Pigment Epithelium-derived Factor, a 
       Protective Factor for Photoreceptors In Vivo -- Part X 
       Retinal Pigment Epithelium (RPE) -- The mTOR Kinase 
       Inhibitor INK128 Blunts Migration of Cultured Retinal     
       Pigment Epithelial Cells -- Live Imaging of LysoTracker- 
       Labelled Phagolysosomes Tracks Diurnal Phagocytosis of 
       Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex
       Vivo -- Cre Recombinase: You Can?t Live with It, and You 
       Can?t Live without It -- Efficiency of Membrane Protein 
       Expression Following Infection with Recombinant Adenovirus
       of Polarized Non-Transformed Human Retinal Pigment      
       Epithelial Cells -- Contribution of Ion Channels in 
       Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 
       and Bestrophin-1 -- Lysosomal Trafficking Regulator (LYST)
       -- Live-cell Imaging of Phagosome Motility in Primary 
       Mouse RPE Cells -- RPE Cell and Sheet Properties in Normal
       and Diseased Eyes -- Valproic Acid Induced Human Retinal 
       Pigment Epithelial Cell Death as Well as its Survival Aft.
520    Contains the proceedings of the XVI International 
       Symposium on Retinal Degeneration (RD2014), held July 13-
       18, 2014 at the Asilomar Conference Center in Pacific 
       Grove, California. A majority of those who spoke and 
       presented posters at the meeting contributed to this 
       volume. The Symposium addressed the blinding diseases of 
       inherited retinal degenerations, which have no effective 
       treatments, and age-related macular degeneration, which 
       has no cures, despite the fact that it is an epidemic 
       among the elderly, with 1 in 3-4 affected by the age of 
       75. The RD2014 Symposium focused on the excitingew  
       developments aimed at understanding these diseases and 
       providing therapies for them. The volume presents 
       representative state-of-the-art research in almost all 
       areas of retinal degenerations, ranging from  
       cytopathologic, physiologic, diagnostic and clinica 
       aspects; animal models; mechanisms of cell death; 
       molecular genetics; and developing potential therapeutic 
       measures such as gene therapy and neuroprotective agents 
       for potential pharmaceutical therapy; and several sight 
       restoration approaches, including optogenetics. While 
       advances in these areas of retinal degenerations are 
       included, several new topics either were in their infancy 
       or did not exist at the time of the last RD Symposium,
       RD2012. These include many new developments in sight 
       restoration using optogenetics, retinal or RPE cell 
       transplantation, stem cell approaches and visual 
       prosthetic devices. In addition, major advances are 
       presented in other basic mechanisms in age-related 
       maculardegeneration, several new aspects of gene and 
       antioxidant therapy, and revolutionary new imaging and 
       functional testing that will have a huge impact on the 
       diagnosis and following the course of retinal 
       degenerations, as well as to provide new quantitative 
       endpoints for clinical trials.The retina is an 
       approachable part of the central nervous system (CNS), and
       there is a major interest in neuroprotective and gene 
       therapy for CNS diseases and neurodegenerations, in 
       general. It should be noted that  with successful and 
       exciting initial clinical trials in neuroprotective and 
       gene therapy, including the restoration of sight in blind 
       children, the retinal  degeneration therapies are leading 
       the way towards new therapeutic measures for 
       neurodegenerations of the CNS.Many of the successes 
       recently reported in these areas of retinal degeneration 
       sprang from collaborations established at previous RD 
       Symposia, and many of those are reported at the RD2014 
       meeting and included in this volume 
650  0 Retinal degeneration 
700 1  Rickman, Catherine Bowes,|eeditor 
830  0 Advances in experimental medicine and biology ;|vv. 854